Diaphragmatic neuromechanical coupling and mechanisms of hypercapnia during inspiratory loading
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- 作者：Franco Laghia ; b ; flaghi@lumc.edu" class="auth_mail ; Hameeda S. Shaikha ; b ; hameeda.shaikh@va.gov" class="auth_mail ; Daniel Moralesa ; danielfm2@hotmail.com" class="auth_mail ; Christer Sinderbyc ; d ; sinderbyc@smh.ca" class="auth_mail ; Amal Jubrana ; b ; ajubran@lumc.edu" class="auth_mail ; Martin J. Tobina ; b ; mtobin2@lumc.edu" class="auth_mail
- 关键词：Respiratory muscles ; Hypercapnia ; Breathing pattern ; Dyspnea ; Muscle fatigue ; Phrenic nerve
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：1 July 2014
- 年：2014
- 卷：198
- 期：Complete
- 页码：32-41
- 全文大小：935 K
文摘
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Progressive inspiratory mechanical loading causes hypercapnia.
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Hypercapnia results mostly from inhibition of central activation to the diaphragm.
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Hypercapnia is accompanied by enhanced diaphragmatic neuromechanical coupling.
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Cortical, and not bulbopontine, areas primarily defend against inspiratory loads.