mTORC1 activation upregulated the proteins in protein nuclear import and glycolysis.
mTORC1 positively regulated KPNA2 expression in multiple cell lines.
S6K1 and 4E-BP1 did not participate in KPNA2 regulation by mTORC1.
mTORC1 regulated KPNA2 at transcriptional level.
mTORC1 regulated glycolysis genes through controlling KPNA2 expression.