Rictor/mTORC2 loss in osteoblasts impairs bone mass and strength
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- 作者：Dong-mei Liua ; 1 ; Lin Zhaoa ; b ; 1 ; Ting-ting Liua ; Pei-lin Jiaoa ; Dian-dian Zhaoa ; Mei-Shu Shihc ; Bei Taoa ; Li-hao Suna ; Hong-yan Zhaoa ; Jian-min Liua ; liujianmin@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rictor ; mTORC2 ; Osteoblasts ; Osteoclasts ; Bone remodeling
- 刊名：Bone
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：50-58
- 全文大小：1408 K
文摘
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Rictor loss in primary osteoblasts retarded osteoblast differentiation along with lowered activity of the mTORC2-Akt (S473) signaling pathway.
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Rictorob-/- mice showed a significant impairment of the cortical bone with minor changes in trabecular bone.
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Bone turnover rate was slowed down in Rictorob-/- mice.
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Significantly decreased bone biomechanical properties were observed in Rictorob-/- mice.