Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation
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- 作者：Stanley Ching-Cheng Huang1 ; Amber M. Smith1 ; Bart Everts4 ; Marco Colonna1 ; Erika L. Pearce5 ; Joel D. Schilling1 ; 2 ; 3 ; Edward J. Pearce5 ; 6 ; 7 ; pearceed@ie-freiburg.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：macrophage ; metabolism ; type 2 immunity ; cancer immunity ; growth-factor signaling ; cytokine signaling
- 刊名：Immunity
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：45
- 期：4
- 页码：817-830
- 全文大小：3430 K
文摘
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IL-4 and CSF-1 promote glucose metabolism during M2, or M(IL-4), macrophage activation.
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IL-4 and CSF-1 signal via mTORC2 and IRF4 to induce changes in glucose metabolism
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Glucose metabolism supports fatty acid synthesis and oxidation in M2 macrophages
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mTORC2- and IRF4-dependent changes in glucose metabolism are critical for M2 activation