Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan?
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- 作者：Alberto Sanz
- 关键词：DCFDA) ; 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; FCCP) ; carbonyl cyanide-p-trifluoromethoxyphenylhydrazone ; CoQ) ; Coenzyme Q ; CI) ; Complex I ; ETC) ; electron transport chain ; H2O2) ; hydrogen peroxide ; HE) ; hydroethidine ; LC) ; liquid chromatography ; MS) ; mass spectrophotometry ; mtDNA) ; mitochondrial DNA ; MFRTA) ; Mitochondrial Free Radical Theory of Aging ; mtROS) ; mitochondrial Reactive Oxygen Species ; mtUPR) ; mitochondrial Unfolded Protein Response ; PD) ; Parkinson's disease
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1857
- 期：8
- 页码：1116-1126
- 全文大小：870 K
文摘
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Data supporting the Mitochondrial Free Radical Theory of Ageing are correlative.
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ROS measurements in isolated mitochondria are prone to experimental artifacts.
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In vivo measurements are required to understand the role of ROS in aging.
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Boosting ROS in worms and flies extends lifespan, contradicting MFRTA.