Presence of DNA extracellular traps but not MUC5AC and MUC5B mucin in mucoid plugs/casts of infectious laryngotracheitis virus (ILTV) infected tracheas of chickens

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• 作者：Vishwanatha R.A.P. Reddy ; ^{reddy.vishwanatha@ugent.be} ; Ivan Trus ^{ivan.trus@ugent.be} ; Hans J. Nauwynck ^{hans.nauwynck@ugent.be}
• 关键词：ILTV ; Mucin ; MUC5AC/MUC5B ; Intraluminal plugs/casts ; Trachea ; Heterophil extracellular traps
• 刊名：Virus Research
• 出版年：2017
• 出版时间：2 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：135-142
• 全文大小：1859 K
• 卷排序：227

文摘

Any change of mucin secretion in larynx, trachea and bronchi, and in trachea with mucoid plugs/casts of ILTV infected chickens was studied. MUC5AC and MUC5B were present only in the dorsal tracheal region of the cranial and middle-tracheal mucosa of control chickens. The tracheal lumen diameter was almost 40% less in ILTV infected chickens due to mucosa thickening. MUC5AC and MUC5B were scarcely observed in larynx, trachea and bronchi, and in trachea with plugs/casts of ILTV infected chickens. Reduced tracheal lumen diameter and DNA fibrous structures connected with nuclei of cells in trachea with plugs/casts were observed in ILTV infected chickens.