Oral mucoceles: A clinical, histopathological and immunohistochemical study

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• 作者：Jamile Gomes Concei莽茫o ; Clarissa Ara煤jo Gurgel ; Eduardo Ant么nio Gon莽alves Ramos ; Fl谩via Cal贸 De Aquino Xavier ; Caroline Br ; i Schlaepfer-Sales ; Maria Cristina Teixeira Cangussu ; Patr铆cia Ramos Cury ; Luciana Maria Pedreira Ramalho ; Jean Nunes Dos Santos
• 关键词：Oral mucoceles ; Histopathology ; Myxoglobulosis ; Immunohistochemistry
• 刊名：Acta Histochemica
• 出版年：January, 2014
• 年：2014
• 卷：116
• 期：1
• 页码：40-47
• 全文大小：3834 K

文摘

The aim of study was to evaluate the clinicopathological features of oral mucoceles and the immunohistochemical expression of cellular and extracellular matrix components in these lesions. One hundred cases of oral mucoceles were examined for clinicopathological features. The expression of mast cell tryptase, CD68, MMP-1 (matrix metalloproteinase-1), MMP-9 (matrix metalloproteinase-9) and CD34 was investigated immunohistochemically in 32 cases. The lesions arose as nodules or blisters of variable color. The mean age was 23.2 years and a higher male frequency was observed. The most common locations were the lower lip (92%), followed by the floor of the mouth (7%), and palate (1%). The lesion size ranged from 0.4 to 3.0 cm. Unusual histopathological findings as superficial mucoceles (n = 16, 16%), pseudopapillary projections (n = 3, 3%), epithelioid histiocytes (n = 4, 4%), multinucleated giant cells (n = 1, 1%) and myxoglobulosis (n = 9, 9%) were also seen. Mast cells and CD68-positive macrophages, MMP-1, MMP-9 and CD34-positive blood vessels were seen in all cases. A significant association was seen between mast cells and MMP-1 (p = 0.03) and between macrophages and MMP-1 (p = 0.01). This study provided important insight into the demographic and histopathological occurrence of oral mucoceles. The tissue remodeling seen in these lesions mainly involved the migration and interaction of mast cells, macrophages and MMP-1.