Oxidative and nitrative stress and pro-inflammatory cytokines in Mucopolysaccharidosis type II patients: effect of long-term enzyme replacement therapy and relation with glycosaminoglycan accumulation
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- 作者：Carlos Eduardo Diaz Jacquesa ; c ; carloseduardo.jacques@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Bruna Donidab ; c ; donida.bruna@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Caroline P. Mesckac ; carolmescka@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Daiane G.B. Rodriguesa ; c ; daianegbr@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Desirè ; e P. Marchettib ; c ; desireepmarchetti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fernanda H. Bitencourtc ; d ; nandahbitencourt@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Maira G. Burinc ; mburin@hcpa.edu.br" class="auth_mail" title="E-mail the corresponding author ; Carolina F.M. de Souzac ; cfsouza@hcpa.edu.br" class="auth_mail" title="E-mail the corresponding author ; Roberto Giuglianic ; d ; rgiugliani@hcpa.edu.br" class="auth_mail" title="E-mail the corresponding author ; Carmen Regla Vargasa ; b ; c ; crvargas@hcpa.edu.br" class="auth_mail" title="E-mail the corresponding author
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1608-1616
- 全文大小：620 K
文摘
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MPS II patients presented higher levels of pro-inflammatory and pro-oxidant biomarkers.
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Lipid peroxidation and oxidative protein damage occurred in MPS II patients.
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No alterations of enzymatic and non-enzymatic defenses were observed in MPS II patients.
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MPS II patients presented higher levels of reactive nitrogen species.
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Nitrative stress and protein damage were positively correlated to GAG accumulation.