Differential response to anodal tDCS and PAS is indicative of impaired focal LTP-like plasticity in schizophrenia
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- 作者：Wolfgang Strubea ; wolfgang.strube@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Tilmann Bunsea ; tilmann.bunse@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Michael A. Nitscheb ; c ; mnitsch1@gwdg.de" class="auth_mail" title="E-mail the corresponding author ; Ulrich Palma ; ulrich.palm@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Peter Falkaia ; peter.falkai@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Alkomiet Hasana ; alkomiet.hasan@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Schizophrenia ; Paired associative stimulation (PAS) ; Anodal transcranial direct current stimulation (tDCS) ; Long term potentiation (LTP) ; Like plasticity ; Focality ; Transcranial magnetic stimulation (TMS)
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：311
- 期：Complete
- 页码：46-53
- 全文大小：1028 K
文摘
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Non-focal and focal plasticity mechanisms were comparatively evaluated.
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Anodal tDCS induced non-focal LTP-like plasticity both in schizophrenia and controls.
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Following PAS, reduced focal LTP-like plasticity was observed in schizophrenia.
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This differential pattern indicates impaired temporal-spatial signal integration.