Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives

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• 作者：Fayaz Ali Larik^a ; Aamer Saeed^a ; ^{aamersaeed@yahoo.com} ; Danish Shahzad^a ; Muhammad Faisal^a ; Hesham El-Seedi^b ; Haroon Mehfooz^a ; Pervaiz Ali Channar^a
• 关键词：Spironolactone ; Canrenone ; Eplerenone ; Synthesis ; Aldosterone
• 刊名：Steroids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：118
• 期：Complete
• 页码：76-92
• 全文大小：2631 K
• 卷排序：118

文摘

Synthetic approaches to the versatile mutitarget drug spironolactone have been reviewed. Aims to provide a comprehensive insight to the synthetic endeavors devoted to drug and its analogues/derivatives. It will help the synthetic chemist to design and prepare new more effective derivatives. The efficacy and limitations of the drug have also been discussed.