Insulin secretion and sensitivity in Bangladeshi prediabetic subjects

详细信息    查看全文

• 作者：Muhammad Hafizur Rahman ; Rahman Muhammad Hafizur ; Qamrun Nahar ; Abdur Rahman Khan ; Liaquat Ali
• 刊名：Journal of Diabetes and its Complications
• 出版年：2010
• 出版时间：January-February 2010
• 年：2010
• 卷：24
• 期：1
• 页码：37-42
• 全文大小：127 K

文摘

Objective

There are still considerable controversies regarding the basic pathophysiological mechanisms of impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). The present study was undertaken to explore the β-cell function and insulin sensitivity in a Bangladeshi prediabetic population.

Methods

Twenty-four IFG and 112 IGT subjects, along with 40 healthy controls, were selected purposively following 2003 ADA cut-off values and 2006 WHO/IDF grouping. IGT subjects were subcategorized into 53 isolated IGT (I-IGT) and 59 combined IFG-IGT subjects. Plasma glucose and insulin (by chemiluminescent immunoassay) were measured at fasting and 2 h after 75 g of oral glucose load. Insulin sensitivity was assessed by homeostasis model assessment (HOMA-S % ) and insulin sensitivity index for glycemia (ISI_gly) and insulin secretion by HOMA-B % .

Results

Compared to control, fasting and 2-h plasma insulin were higher in I-IGT and IFG-IGT subjects; similarly, HOMA-S % [median (range)] was lower in I-IGT and IFG-IGT subjects [116 (54–227) vs. 93 (23–187) and 79 (32–197) % , P<.05 and P<.001]; ISI_gly was also lower in I-IGT and IFG-IGT subjects [0.95 (0.54–1.64) vs. 0.64 (0.26–1.24) and 0.65 (0.29–1.20), P<.001]. But HOMA-B % was compromised in IFG and IFG-IGT groups [88 (59–182) vs. 68 (37–107) and 74 (36–141) % , P<.001 and P<.05]. The IGT group (combination of I-IGT and IFG-IGT) showed higher fasting and 2-h insulin, and lower HOMA-S % as well as ISI_gly, but compromised HOMA-B % was not evident.

Conclusions

The pathophysiological mechanisms differ in IFG (having B-cell dysfunction) and I-IGT (an insulin-resistant condition). The pathophysiology of IFG-IGT (having both B-cell dysfunction and insulin resistance) indicates that it may be a different entity and not be included in IGT.