Alpha-lipoic acid-mediated activation of muscarinic receptors improves hippocampus- and amygdala-dependent memory
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- 作者：Aamra Mahbooba ; Syeda Mehpara Farhata ; Ghazala Iqbala ; Mustafeez Mujtaba Babarb ; Najam-us-Sahar Sadaf Zaidib ; Seyed Mohammad Nabavic ; Touqeer Ahmeda ; touqeer.aahmed@gmail.com" class="auth_mail" title="E-mail the corresponding author ; touqeer.ahmed@asab.nust.edu.pk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cholinergic receptors ; Alpha-lipoic acid ; Memory ; Hippocampus ; Choline acetyltransferase ; Amygdala
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：19-28
- 全文大小：3152 K
文摘
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id="par0005">Alpha lipoic acid (ALA) significantly enhances learning and memory.
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id="par0010">Al-induced neurodegeneration is reverted by ALA.
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id="par0015">ALA improves the expression of muscarinic receptors (M1 and M2).
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id="par0020">ALA has higher binding affinity for M1 and M2 as compared to acetylcholine.