Stereoselective synthesis of the C1–C10 fragment of rhizoxin D

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• 作者：Srinivas Padakanti ; Manojit Pal ; K. Mukkanti and Javed Iqbal
• 关键词：Rhizoxin ; Stereoselective Michael addition
• 刊名：Tetrahedron Letters
• 出版年：2006
• 出版时间：14 August 2006
• 年：2006
• 卷：47
• 期：33
• 页码：5969-5971
• 全文大小：117 K

文摘

A novel approach towards the synthesis of the C1–C10 fragment of the biologically active antimitotic agent rhizoxin D is described. The synthesis involves a stereoselective Michael addition reaction of lithium diallyl cuprate with an α,β-unsaturated six membered lactone.