Stereoselective synthesis of an advanced seco ester intermediate as a precursor toward the synthesis of amphidinolides T1, T3, and T4
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- 作者：Pradip K. Sasmal ; Ch ; rasekhar Abbineni ; Javed Iqbal ; K. Mukkanti
- 关键词：Amphidinolide T family ; Evan’ ; s aldol ; Evan’ ; s alkylation ; Oxy-Michael ; Cross metathesis ; CBS reduction
- 刊名：Tetrahedron
- 出版年：2010
- 出版时间：3 July 2010
- 年：2010
- 卷：66
- 期：27-28
- 页码：5000-5007
- 全文大小：439 K
文摘
An efficient, convergent, and stereoselective synthesis of a very advanced intermediate toward the total synthesis of amphidinolides T1, T3, and T4 utilising Evan’s aldol and alkylation reactions, oxy-Michael, cross metathesis, stereoselective Grignard addition, and Yamaguchi esterification reactions as key steps is described.