Comparison of the adjuvant activity of emulsions with different physicochemical properties on the antibody response towards the venom of West African carpet viper (Echis ocellatus)

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• 作者：Juan Manuel Valverde^a ; Karina Rodrí ; guez^b ; Marí ; a Herrera^a ; ^c ; Á ; lvaro Segura^a ; Mariá ; ngela Vargas^a ; Mauren Villalta^a ; Mavis Montero^b ; Jose Marí ; a Gutié ; rrez^a ; Guillermo Leó ; n^a ; ^{guillermo.leon@ucr.ac.cr}
• 关键词：Adjuvants ; Emulsions ; Antibody response ; Snake venom ; Echis ocellatus
• 刊名：Toxicon
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：106-111
• 全文大小：637 K
• 卷排序：127

文摘

Emulsions are widely used to enhance the response of the animals used as immunoglobulin source for producing antivenoms. The mechanism by which emulsions exert their adjuvant activity is complex and not completely understood. We compared the adjuvant activity of emulsions with different physicochemical properties. It was found that the 50/50 (W/O) and the multiple emulsion (W/O/W) were those that induced the higher antibody response. Adjuvant activity of emulsions is not associated to their ability to form depots from which the venom is slowly released.