We collected electroencephalographic (EEG) data in 18 people with mild MS, while they were in resting state with open eyes. To ensure a wide range of fatigue, we enrolled patients to have Higher- or Lower-Fatigue based on scores of the modified Fatigue Impact Scale (mFIS). We selected the graph theory small-world index, calculated on networks of cortical nodes estimated by eLORETA, to evaluate the characteristics of left and right frontal (Motor) and parieto-occipital-temporal (Sensory) brain networks separately.
Fatigue symptoms increased together with the small-world index in the Sensory network of the left dominant hemisphere.
This finding hones understanding of the targets of neuromodulation interventions indicating the sensory network of the dominant left hemisphere as a specific target.