Parallel reaction monitoring of clinical Mycobacterium tuberculosis lineages reveals pre-existent markers of rifampicin tolerance in the emerging Beijing lineage
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- 作者：Jeroen de Keijzera ; j.de_keijzer@lumc.nl" class="auth_mail" title="E-mail the corresponding author ; Arnout Mulderb ; Arnoud H. de Rua ; c ; Dick van Soolingenb ; d ; 1 ; Peter A. van Veelena ; c ; 1
- 关键词：CAS ; Central Asian strains ; DDA ; data dependent acquisition ; EAI ; East-African Indian ; FDR ; false discovery rate ; FASP ; filter aided sample preparation ; MIC ; minimal inhibitory concentration ; MDR-TB ; multidrug resistant tuberculosis ; MGIT ; mycobacterial growth indicator tube ; MIRU ; mycobacterial interspersed repeat units ; nsSNP ; non synonymous single nucleotide polymorphisms ; PRM ; parallel reaction monitoring ; RRDR ; rifampicin resistance determining region ; SIL ; stable isotopically labelled ; SCX
- 刊名：Journal of Proteomics
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：150
- 期：Complete
- 页码：9-17
- 全文大小：952 K
文摘
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The proteomic composition of M. tuberculosis Beijing and H37Rv were compared.
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Both M. tuberculosis Beijing and H37Rv induce dormancy proteins as a shared response upon exposure to rifampicin.
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The abundance of PhoPR regulon proteins is conserved in clinical strains of M. tuberculosis.
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The dormancy regulators Rv3132c/devS and Rv3133c/devR are more abundant in M. tuberculosis Beijing.