Asynchronous Distributed Multielectrode Microstimulation Reduces Seizures in the Dorsal Tetanus Toxin Model of Temporal Lobe Epilepsy
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- 作者：Sharanya Arcot Desaia ; b ; John D. Rolstonc ; Courtney E. McCrackend ; Steve M. Pottera ; b ; Robert E. Grossa ; e ; rgross@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Epilepsy ; Microstimulation ; Theta oscillations ; Multi-site stimulation ; Multielectrode array
- 刊名：Brain Stimulation
- 出版年：2016
- 出版时间：January-February 2016
- 年：2016
- 卷：9
- 期：1
- 页码：86-100
- 全文大小：1993 K
文摘
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Theta oscillations were found to be decreased in the rodent tetanus toxin model of non-lesional hippocampal epilepsy.
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Asynchronous distributed-multielectrode-microstimulation (DMM) at theta frequencies reduced seizures by ~46%.
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We suggest DMM as a new approach to therapeutic brain stimulation for the treatment of epilepsy.