Multifunctional Nanoprobes for Cancer Cell Targeting, Imaging and Anticancer Drug Delivery

详细信息    查看全文

• 作者：Pavel Linkov^a ; ^b ; ^c ; ^{valinkov@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marie Laronze-Cochard^c ; Janos Sapi^c ; Lev N. Sidorov^d ; Igor Nabiev^a ; ^b
• 关键词：multifunctional nanoprobe ; quantum dots ; multishell nanocrystals ; quantum yield ; drug delivery ; two-photon imaging ; intracellular imaging ; nucleus-targeted delivery ; cell-penetrating.
• 刊名：Physics Procedia
• 出版年：2015
• 出版时间：2015
• 年：2015
• 卷：73
• 期：Complete
• 页码：216-220
• 全文大小：1286 K

文摘

The diagnosis and treatment of cancer have been greatly improved with recent developments in bio-nanotechnology, including engineering of multifunctional probes. One of the promising nanoscale tools for cancer imaging is fluorescent quantum dots (QDs), whose small size and unique optical properties allow them to penetrate into cells and ensure highly sensitive optical diagnosis of cancer at the cellular level. Furthermore, novel multi-functional probes have been developed in which QDs are conjugated with one or several functional molecules, including targeting moieties and therapeutic agents. Here, the strategy for engineering novel nanocarriers for controlled nucleus-targeted antitumor drug delivery and real-time imaging by single- or two-photon microscopy is described. A triple multifunctional nanoprobe is being developed that consists of a nitrogen-based heterocyclic derivative, an anticancer agent interacting with a DNA in living cells; a recognized molecule serving as a vector responsible for targeted delivery of the probe into cancer cells; and photoluminescent QDs providing the imaging capability of the probe. Subsequent optimization of the multifunctional nanoprobe will offer new possibilities for cancer diagnosis and treatment.