Comparative effectiveness and safety of thalidomide and lenalidomide in patients with multiple myeloma in the United States of America: A population-based cohort study
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- 作者：Jing Luo ; jluo1@partners.org ; Joshua J. Gagne ; Joan Landon ; Jerry Avorn ; Aaron S. Kesselheim
- 关键词：Thalidomide ; Lenalidomide ; Myeloma ; Comparative effectiveness ; Peripheral neuropathy ; Survival
- 刊名：European Journal of Cancer
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：70
- 期：Complete
- 页码：22-33
- 全文大小：545 K
- 卷排序：70
文摘
The comparative effectiveness and safety of thalidomide and lenalidomide for myeloma treatment has not been established. Our observational study assessed the risk of death or neuropathy comparing new initiators of thalidomide or lenalidomide. We found that patients starting these drugs had an equivalent risk of death but different risk for neurotoxicity.