Nifedipine nanoparticle agglomeration as a dry powder aerosol formulation strategy
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- 作者：Carl Plumley ; Eric M. Gorman ; Nashwa El-Gendy ; Connor R. Bybee ; Eric J. Munson ; Cory Berkl
- 关键词：Drug delivery ; Nanoparticles ; Nifedipine ; Dry powder aerosol
- 刊名：International Journal of Pharmaceutics
- 出版年：2009
- 出版时间：18 March 2009
- 年：2009
- 卷：369
- 期：1-2
- 页码：136-143
- 全文大小：640 K
文摘
Efficient administration of drugs represents a leading challenge in pulmonary medicine. Dry powder aerosols are of great interest compared to traditional aerosolized liquid formulations in that they may offer improved stability, ease of administration, and simple device design. Particles 1–5 μm in size typically facilitate lung deposition. Nanoparticles may be exhaled as a result of their small size; however, they are desired to enhance the dissolution rate of poorly soluble drugs. Nanoparticles of the hypertension drug nifedipine were co-precipitated with stearic acid to form a colloid exhibiting negative surface charge. Nifedipine nanoparticle colloids were destabilized by using sodium chloride to disrupt the electrostatic repulsion between particles as a means to achieve the agglomerated nanoparticles of a controlled size. The aerodynamic performance of agglomerated nanoparticles was determined by cascade impaction. The powders were found to be well suited for pulmonary delivery. In addition, nanoparticle agglomerates revealed enhanced dissolution of the drug species suggesting the value of this formulation approach for poorly water-soluble pulmonary medicines. Ultimately, nifedipine powders are envisioned as an approach to treat pulmonary hypertension.