Enhanced tumor growth in the remaining lung after major lung resection

详细信息    查看全文

• 作者：Fumiho Sano ; MD ; Kazuhiro Ueda ; MD ; ^{kaueda@c-able.ne.jp" class="auth_mail" title="E-mail the corresponding author} ; Junichi Murakami ; MD ; Masataro Hayashi ; MD ; Arata Nishimoto ; PhD ; Kimikazu Hamano ; MD
• 关键词：Microenvironment ; Compensatory lung growth ; Pulmonary resection ; Lung cancer ; Monocyte chemoattractant protein-1
• 刊名：Journal of Surgical Research
• 出版年：2016
• 出版时间：1 May 2016
• 年：2016
• 卷：202
• 期：1
• 页码：1-7
• 全文大小：923 K

文摘

Pneumonectomy induces active growth of the remaining lung in order to compensate for lost lung tissue. We hypothesized that tumor progression is enhanced in the activated local environment.

Methods

We examined the effects of mechanical strain on the activation of lung growth and tumor progression in mice. The mechanical strain imposed on the right lung after left pneumonectomy was neutralized by filling the empty space that remained after pneumonectomy with a polypropylene prosthesis.

Results

The neutralization of the strain prevented active lung growth. According to an angiogenesis array, stronger monocyte chemoattractant protein-1 (MCP-1) expression was found in the strain-induced growing lung. The neutralization of the strain attenuated the release of MCP-1 from the lung cells. The intravenous injection of Lewis lung cancer cells resulted in the enhanced development of metastatic foci in the strain-induced growing lung, but the enhanced development was canceled by the neutralization of the strain. An immunohistochemical analysis revealed the prominent accumulation of tumor-associated macrophages in tumors arising in the strain-induced growing lung, and that there was a relationship between the accumulation and the MCP-1 expression status.

Conclusions

Our results suggested that mechanical lung strain, induced by pulmonary resection, triggers active lung growth, thereby creating a tumor-friendly environment. The modification of that environment, as well as the minimizing of surgical stress, may be a meaningful strategy to improve the therapeutic outcome after lung cancer surgery.