Information in pallidal neurons increases with parkinsonian severity
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- 作者：Alan D. Dorvala ; chuck.dorval@utah.edu" class="auth_mail" title="E-mail the corresponding author ; Abirami Muralidharanb ; Alicia L. Jensenb ; Kenneth B. Bakerb ; Jerrold L. Vitekb
- 关键词：Basal ganglia ; Globus pallidus ; Parkinson's disease ; Neural information
- 刊名：Parkinsonism & Related Disorders
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：21
- 期：11
- 页码：1355-1361
- 全文大小：1172 K
文摘
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Quantified information between pallidal neurons in primate model of progressive PD.
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Information transmitted from GPe to GPi increased with symptom severity.
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Antidromic information from GPi to GPe increased with symptom severity.
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With progression, direct & indirect pathways start to convey redundant information.
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Hypothesize loss of parallel processing promotes hypokinetic symptoms of PD.