Current topics in autoimmune hepatitis
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- 作者：Luigi Muratori ; Paolo Muratori ; Aless ; ro Granito ; Giorgios Pappas ; Fabio Cassani ; Marco Lenzi
- 关键词：Autoantibodies ; Autoimmune hepatitis ; Diagnosis ; Liver ; Therapy
- 刊名：Digestive and Liver Disease
- 出版年：2010
- 出版时间：November 2010
- 年：2010
- 卷：42
- 期：11
- 页码：757-764
- 全文大小：328 K
文摘
Autoimmune hepatitis is a chronic liver disease of unknown aetiology characterized by interface hepatitis, hypergammaglobulinaemia and circulating autoantibodies. In the last decade a number of advancements have been made in the field of clinical and basic research: the simplified diagnostic criteria, the complete response defined as normalization of transaminase levels, the molecular identification of the antigenic targets of anti-liver cytosol antibody type 1 and anti-soluble liver antigen, the detection of anti-actin antibodies, the description of de novo autoimmune hepatitis after liver transplantation for non-autoimmune liver diseases, the characterization of autoimmune hepatitis with overlapping features of primary biliary cirrhosis or primary sclerosing cholangitis, the preliminary experience with novel treatment strategies based on cyclosporine, mycophenolate mofetil and budesonide, the role played by “impaired” regulatory T cells and the development of novel animal models of autoimmune hepatitis.