Optimal Titration Is Important to Maximize the Beneficial Effects of Vagal Nerve Stimulation in Chronic Heart Failure
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- 作者：Akiko Nishizaki ; MD1 ; nishizak@cardiol.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kazuo Sakamoto ; MD ; PhD2 ; Keita Saku ; MD ; PhD3 ; Kazuya Hosokawa ; MD ; PhD1 ; Takafumi Sakamoto ; MD ; PhD1 ; Yasuhiro Oga ; MD1 ; Takuya Akashi ; MS3 ; Yoshinori Murayama ; MS1 ; Takuya Kishi ; MD ; PhD3 ; Tomomi Ide ; MD ; PhD1 ; Kenji Sunagawa ; MD ; PhD3
- 关键词：Vagal nerve stimulation ; Chronic heart failure ; Myocardial infarction
- 刊名：Journal of Cardiac Failure
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：22
- 期：8
- 页码：631-638
- 全文大小：750 K
文摘
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This is the 1st report on dose response of vagal nerve stimulation (VNS) in a rat model of chronic heart failure.
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VNS at 50% of the symptom threshold significantly improved cardiac function.
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VNS at just below the symptom threshold injured vagal nerve histologically.
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Optimal titration maximizes the beneficial effects of VNS on chronic heart failure.