- 作者：Pedro Marques-Vidal ; Nicolas Rodondi ; Murielle Bochud ; Arnaud Chiolero ; Alain Pé ; coud ; Daniel Hayoz ; Fred Paccaud ; Vincent Mooser ; Mathieu Firmann ; Gé ; rard Waeber ; Peter Vollenweider
- 刊名：International Journal of Cardiology
- 出版年：2009
- 出版时间：17 April 2009
- 年：2009
- 卷：133
- 期：3
- 页码：346-353
- 全文大小：225 K
ObjectiveTo compare the predictive accuracy of the original and recalibrated Framingham risk function on current morbidity from coronary heart disease (CHD) and mortality data from the Swiss population.Methods
Data from the CoLaus study, a cross-sectional, population-based study conducted between 2003 and 2006 on 5,773 participants aged 35–74 without CHD were used to recalibrate the Framingham risk function. The predicted number of events from each risk function were compared with those issued from local MONICA incidence rates and official mortality data from Switzerland.
Results
With the original risk function, 57.3 % , 21.2 % , 16.4 % and 5.1 % of men and 94.9 % , 3.8 % , 1.2 % and 0.1 % of women were at very low (< 6 % ), low (6–10 % ), intermediate (10–20 % ) and high (> 20 % ) risk, respectively. With the recalibrated risk function, the corresponding values were 84.7 % , 10.3 % , 4.3 % and 0.6 % in men and 99.5 % , 0.4 % , 0.0 % and 0.1 % in women, respectively. The number of CHD events over 10 years predicted by the original Framingham risk function was 2–3 fold higher than predicted by mortality + case fatality or by MONICA incidence rates (men: 191 vs. 92 and 51 events, respectively). The recalibrated risk function provided more reasonable estimates, albeit slightly overestimated (92 events, 5–95th percentile: 26–223 events); sensitivity analyses showed that the magnitude of the overestimation was between 0.4 and 2.2 in men, and 0.7 and 3.3 in women.
Conclusion
The recalibrated Framingham risk function provides a reasonable alternative to assess CHD risk in men, but not in women.