Smoking offsets the metabolic benefits of parental longevity in women: The CoLaus study

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• 作者：Jerome Jaunin ; Murielle Bochud ; Pedro Marques-Vidal ; Peter Vollenweider ; Gé ; rard Waeber ; Vincent Mooser ; Fred Paccaud
• 关键词：Aging ; Cardiovascular disease ; Obesity ; Epidemiology ; Smoking ; Family history
• 刊名：Preventive Medicine
• 出版年：2009
• 出版时间：March 2009
• 年：2009
• 卷：48
• 期：3
• 页码：224-231
• 全文大小：408 K

文摘

Objective

We evaluated whether subjects with long-lived parents show lower levels of cardiovascular risk factors, including the metabolic syndrome.

Methods

We analyzed data from a Swiss population-based sample (1163 men and 1398 women) aged 55–75 years from Lausanne. Participants were stratified by number of parents (0, 1, 2) who survived to 85 years or more. The associations of parental longevity with cardiovascular risk factors and related metabolic variables were analyzed using multiple linear regressions.

Results

Age-adjusted metabolic syndrome prevalence varied from 24.8 % , 20.5 % to 13.8 % in women (P < 0.05) and from 28.8 % , 32.1 % to 27.6 % in men (not significant) with 0, 1 and 2 long-lived parents. The association between parental longevity and metabolic syndrome prevalence was particularly strong in women who had never smoked. In this group, women with 2 long-lived parents had lower Body Mass Index and smaller waist circumference. In never-smokers of both genders, mean (95 % CI) adjusted High Density Lipoprotein-cholesterol levels were 1.64(1.61–1.67), 1.67(1.65–1.70) and 1.71(1.65–1.76) mmol/L for 0, 1 and 2 long-lived parents (P < 0.01), respectively. The trend was not significant in former and current smokers.

Conclusions

In women, not in men, parental longevity is associated with a better metabolic profile. The metabolic benefits of having long-lived parents are offset by smoking.