Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients
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- 作者：Gabriela Jimé ; nez-Valerio1 ; Mar Martí ; nez-Lozano1 ; Nicklas Bassani1 ; August Vidal2 ; Marí ; a Ochoa-de-Olza3 ; 4 ; Cristina Suá ; rez4 ; Xavier Garcí ; a-del-Muro3 ; Joan Carles4 ; Francesc Viñ ; als1 ; 5 ; Mariona Graupera6 ; Stefano Indraccolo7 ; Oriol Casanovas1 ; ocasanovas@iconcologia.net" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：15
- 期：6
- 页码：1134-1143
- 全文大小：6904 K
文摘
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Resistance to antiangiogenic therapy involves metabolic symbiosis patterning in RCC
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mTOR pathway mediates this resistance and mTOR inhibition blocks metabolic symbiosis
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In patients, antiangiogenics induce symbiotic patterning mostly in resistant tumors
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mTOR pathway implication is also suggested in patients treated with antiangiogenics