Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch
详细信息 查看全文
- 作者：Daniel T. MacLeod
- 刊名：Immunity
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：44
- 期：5
- 页码：1215-1226
- 全文大小：2204 K
文摘
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- <p id="p0010">N332-site Abs with low somatic mutation and no indels achieve broad neutralizationp>
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- <p id="p0015">N332-bnAb lineage diversifies early into multiple limbsp>
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- <p id="p0020">Independent maturation of lineage limbs leads to diverse N332-site bnAb recognitionp>
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- <p id="p0025">Abs to the N332 site show CDRH3s with extended “dagger”-like shapesp>