From organophosphate poisoning to diabetes mellitus: The incretin effect

详细信息    查看全文

• 作者：D. Rathish^a ; ^{rathishdeva@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; S.B. Agampodi^b ; M.A.C.S. Jayasumana^a ; S.H. Siribaddana^c
• 关键词：ACh ; acetylcholine ; AChE ; acetylcholinesterases ; DPP4 ; di-peptidyl peptidase 4 ; FBG ; fasting blood glucose ; GIP ; Glucose-dependent Insulinotropic Polypeptide ; GLP-1 ; Glucagon Like Peptide-1 ; HbA1C ; glycated hemoglobin ; M1 & M2 ; muscarinic receptor type 1 & 2 ; MBBS ; bachelor of medicine ; bachelor of surgery ; OGTT ; oral glucose tolerance test ; OP ; organophosphate ; SPSS ; statistical package for the social science ; T2DM ; type 2 diabetes mellitus
• 刊名：Medical Hypotheses
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：91
• 期：Complete
• 页码：53-55
• 全文大小：285 K

文摘

Organophosphate (OP) poisoning induced disruption of glucose homeostasis is well established. OP poisoning leads to accumulation of acetylcholine (ACh) due to the inhibition of acetylcholinesterases (AChE). On the other hand the incidence of type 2 diabetes mellitus (T2DM) is shown to rise along with the use of pesticides in Southeast Asia. Attenuation of the ‘incretin effect’ is seen in T2DM. This effect is regulated by a complex loop of mechanism involving ACh driven muscarinic receptors. We hypothesize that OP poisoning leads to disruption of glucose homeostasis by attenuation of the incretin effect. Inhibition of the Glucagon Like Peptide-1 (GLP-1) secretion is our main focus of interest. Positive finding of the hypothesis will open possibility of using incretin based treatment modalities to treat or prevent acute OP induced disruption of glucose homeostasis.