BDNF and GDNF serum levels in alcohol-dependent patients during withdrawal

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• 作者：Annemarie Heberlein ; Marc Muschler ; Julia Wilhelm ; Helge Frieling ; Bernd Lenz ; Michael Grö ; schl ; Johannes Kornhuber ; Stefan Bleich ; Thomas Hillemacher
• 关键词：Alcohol dependence ; Alcohol withdrawal ; BDNF ; GDNF ; Neurotrophic growth factors ; Craving
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2010
• 出版时间：16 August 2010
• 年：2010
• 卷：34
• 期：6
• 页码：1060-1064
• 全文大小：238 K

文摘

Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) modulate addictive behaviour. Therefore we investigated alterations in BDNF (81 male patients) and GDNF serum levels (52 male patients) in alcohol-dependent patients during alcohol withdrawal (day 1, 7 and 14) in comparison to healthy controls (41 male controls).

BDNF serum levels were not significantly altered in alcohol-dependent patients compared to healthy controls (p = 0.685). GDNF serum levels were significantly reduced in the alcohol-dependent patients (p < 0.001). BDNF (p = 0.265) and GDNF (p = 0.255) serum levels did not change significantly during alcohol withdrawal. BDNF serum levels were significantly negatively associated with alcohol withdrawal severity on day 1 (CIWA-Ar score, p = 0.004). GDNF serum levels were significantly negatively associated with individual estimation of alcohol tolerance (SESA-XT score, p = 0.028). There was no further association with psychometric dimensions of alcohol withdrawal.

In conclusion we found that GDNF serum levels are significantly reduced in alcohol-dependent patients. GDNF serum levels were negatively associated with alcohol tolerance. Moreover BDNF serum levels were found to be associated with withdrawal severity.