BACH1, the master regulator gene: A novel candidate target for cancer therapy
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- 作者：Sadaf Davudiana ; b ; Behzad Mansooria ; Neda Shajaria ; b ; Ali Mohammadia ; Behzad Baradarana ; behzad_im@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BACH1 ; BTB and CNC homology 1 ; basic leucine zipper transcription factor 1 ; CNC ; cap &lsquo ; n&rsquo ; collar ; bZIP ; basic leucine zipper ; HO-1 ; hemoxygenas-1 ; MMP1 ; matrix metalloproteinase-1 ; CXCR4 ; C&ndash ; X&ndash ; C chemokine receptor type 4 ; AP-1 ; activator protein 1 ; MAF ; transcription factor Maf (musculoaponeurotic fibrosarcoma) ; CREB ; cAMP response element-binding protein ; ATF ; activating transcription factor ; C/EBPs ; CCAAT-enhancer-binding proteins ; PAR ; protease-activated receptors ; NRL
- 刊名：Gene
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：588
- 期：1
- 页码：30-37
- 全文大小：506 K
文摘
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BACH1 is a CNC-bZIP transcription factor.
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BACH1 controls the gene transcription through forming a heterodimer with small Maf family.
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BACH1 is a heme-binding transcription factor and known as a repressor of HMOX1.
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BACH1 is involved in heme degradation, redox regulation, cell cycle, apoptosis pathways and subcellular transport processes.
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BACH1 augments the breast cancer bone metastasis through up-regulating metastatic genes like MMP1 and CXCR4.