Protective effects of high Tryptophan diet on aging-induced passive avoidance impairment and hippocampal apoptosis

详细信息    查看全文

• 作者：Giuseppe Musumeci¹ ; ^{giumusu@gmail.com} ; Paola Castrogiovanni¹ ; ^{pacastro@unict.it} ; Marta Anna Szychlinska ^{marta.sz@hotmail.it} ; Rosa Imbesi ^{roimbesi@unict.it} ; Carla Loreto ^{carla.loreto@unict.it} ; Sergio Castorina ^{sergio.castorina@unict.it} ; Salvatore Giunta ; ^{salvatore.giunta15@virgilio.it} ; ^{sgiunta@unict.it}
• 关键词：Serotonin ; Hippocampus ; Learning ; Apoptotic molecules ; CREB
• 刊名：Brain Research Bulletin
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：128
• 期：Complete
• 页码：76-82
• 全文大小：1600 K
• 卷排序：128

文摘

We used 26–30 months-old rats as a physiological model of aging. High TrP diet improves passive avoidance behaviour of aged rats. High TrP diet prevents age-related hippocampal apoptosis. High TrP diet affects the expression of BAX, Bcl-2 and Caspase-3. Enhanced TrP intake partially restored CREB phosphorylation in old rat Hippocampus.