A homolog of the variola virus B22 membrane protein contributes to ectromelia virus pathogenicity in the mouse footpad model

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• 作者：Sara E. Reynolds^a ; ^b ; Patricia L. Earl^a ; Mahnaz Minai^c ; Ian Moore^c ; Bernard Moss^a ; ^{bmoss@nih.gov}
• 关键词：Poxvirus ; Viral pathogenicity ; Host defense ; Innate immunity ; T cells ; Ectromelia virus
• 刊名：Virology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：501
• 期：Complete
• 页码：107-114
• 全文大小：1241 K
• 卷排序：501

文摘

The C15 membrane protein of ectromelia virus is 91% identical to variola virus B22. C15 expression is not required for replication of ectromelia virus in mouse cells. Ectromelia virus C15 null mutant is attenuated in the mouse foot pad model. Survival of infected mice is dependent on CD4+ and CD8+ T cells.