A mechanism for propagated SOD1 misfolding from frustration analysis of a G85R mutant protein assembly
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- 作者：Eamonn F. Healy healy@stedwards.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Superoxide dismutase ; Amyotrophic lateral sclerosis ; Electrostatic loop ; G85R SOD1 mutant ; Frustration contacts ; Dehydrons
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：478
- 期：4
- 页码：1634-1639
- 全文大小：1626 K
文摘
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Frustration analysis of the G85R superoxide dismutase (SOD1) mutant crystal structure.
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A proposed mechanism for prion-like propagation of SOD1 misfolding.
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A local mechanism based on induced conformational change at the electrostatic loop.
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A local mechanism based on the disruption of correlated motion between SOD1 subunits.