Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background
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- 作者：Tim Wolfa ; Wenjing Qia ; Verena Schindlera ; Eva Diana Runkela ; d ; Ralf Baumeistera ; b ; c ; d ; baumeister@celegans.de" class="auth_mail
- 关键词：daf-18/PTEN ; shc-1/ShcA ; Mitochondria ; Metabolic rate ; Doxycyclin ; Tumor
- 刊名：Experimental Gerontology
- 出版年：August 2014
- 年：2014
- 卷：56
- 期：Complete
- 页码：114-122
- 全文大小：852 K
文摘
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daf-18 and shc-1;daf-18 mutants develop a disrupted gonad after L1 starvation
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hyper-proliferation and basement membrane disruption characterize this phenotype
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daf-2(lf) restores proper gonad development in a DAF-16 independent manner
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doxycyclin and starvation temperature decrease suffice to reduce phenotypic penetrance