Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors
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- 作者：Ajmal Khana ; b ; Jamshed Hashima ; jamshed.hashim@iccs.edu" class="auth_mail" title="E-mail the corresponding author ; Nuzhat Arshada ; c ; Ijaz Khana ; Naureen Siddiquia ; Abdul Wadoodd ; Muzaffar Alia ; Fiza Arshada ; Khalid Mohammed Khana ; M. Iqbal Choudharya ; e ; iqbal.choudhary@iccs.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：4-Dihydropyrimidine-2-thione ; Hydrazine derivatives of dihydropyrimidine ; Urease inhibition ; Helicobacter pylori ; Peptic ulcer ; Proteus mirabilis ; Urolithiasis ; Cytotoxicity
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：85-96
- 全文大小：2367 K
文摘
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Urease inhibitory activity of our recently designed four different DHPM series.
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Among them two series were identified as significant inhibitors of urease enzyme.
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Molecular docking and kinetics in order to understand their mode of inhibition.
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The cytotoxicity was also examined and no toxicity was observed.
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These compounds are interesting for urease inhibitory developments.