LC assay method for oxfendazole and oxyclozanide in pharmaceutical preparation

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• 作者：Rafiq Khan ; Abdul ; Jamil Akhtar ; M. ; Mahmood ; Rizwan ; Muied Ahmed ; S. ; Malook ; S. ; Iqbal ; Muzaffar
• 关键词：RP-LC ; Isocratic elution ; Oxfendazole ; Oxyclozanide
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2000
• 出版时间：February, 2000
• 年：2000
• 卷：22
• 期：1
• 页码：111-114
• 全文大小：63.6 K

文摘

A method has been developed for the simultaneous determination of oxfendazole and oxyclozanide in a pharmaceutical preparation. The method involves reversed phase chromatography with isocratic elution of the mobile phase and detection at 300 nm. The range of quantification for oxfendazole and oxyclozanide was found to be 2–7 μg ml⁻¹ and 3–10 μg ml⁻¹, respectively. The validity of the method was evaluated in terms of linear regression analysis, precision, specificity and accuracy.