Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis

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• 作者：Nighat Nazir ; Surrinder Koul ; Mushtaq Ahmad Qurishi ; Muzaffar Hussain Najar ; Mohammed Iqbal Zargar
• 关键词：Regioselective ; Bergenin ; Bergenia stracheyi ; DPPH ; Xanthine oxidase
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：46
• 期：6
• 页码：2415-2420
• 全文大小：251 K

文摘

Bergenin pentacetate (2), a peracetate derivative of biologically active lead compound Bergenin (1) isolated from Bergenia stracheyi was subjected to lipase catalyzed regioselective alcoholysis to obtain 3,4,10,11-tetracetate of Bergenin (3). The free hydroxyl group of 3 was derivatised using higher carboxylic acids to obtain acyl derivatives (4–7). These compounds synthesized via chemoenzymatic route were characterized using ¹H NMR, ¹³C NMR and mass spectral data and evaluated for DPPH radical scavenging, antimicrobial and xanthine oxidase inhibitory activities. The studies revealed that biological activity of Bergenin can be optimized by selective modification of its structure.