Prophylactic use of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia: a randomized, double-blinded, placebo-controlled study

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• 作者：Vinit K. Srivastava^a ; ^{drvinit75@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sanjay Agrawal^b ; Vikrant K. Nimbhorkar^a ; Abhishek Mishra^a ; Sunil Sharma^a ; Prasanta K. Panda^a
• 关键词：Pregabalin ; Succinylcholine ; Fasciculation ; Myalgia
• 刊名：Brazilian Journal of Anesthesiology (English Edition)
• 出版年：2016
• 出版时间：March-April 2016
• 年：2016
• 卷：66
• 期：2
• 页码：165-170
• 全文大小：481 K

文摘

Succinylcholine is commonly used to achieve profound neuromuscular blockade of rapid onset and short duration.

Objective

The present study compared the efficacy of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia.

Design

Prospective, randomized, placebo controlled, double blinded study.

Materials and methods

Patients of both genders undergoing elective spine surgery were randomly assigned to two groups. Patients in Group P (pregabalin group) received 150 mg of pregabalin orally 1 h prior to induction of anesthesia with sips of water and patients in Group C (control group) received placebo. Anesthesia was induced with fentanyl 1.5 mcg/kg, propofol 1.5–2.0 mg/kg followed by succinylcholine 1.5 mg/kg. The intensity of fasciculations was assessed by an observer blinded to the group allotment of the patient on a 4-point scale. A blinded observer recorded postoperative myalgia grade after 24 h of surgery. Patients were provided patient-controlled analgesia with fentanyl for postoperative pain relief.

Results

Demographic data of both groups were comparable (p > 0.05). The incidence of muscle fasciculation's was not significant between two groups (p = 0.707), while more patients in group C had moderate to severe fasciculation's compared to group P (p = 0.028). The incidence and severity of myalgia were significantly lower in group P (p < 0.05).

Conclusion

Pregabalin 150 mg prevents succinylcholine-induced fasciculations and myalgia and also decreases the fentanyl consumption in elective sine surgery.