Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity
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- 作者：Maartje G. Huijbersa ; b ; M.G.M.Huijbers@lumc.nl" class="auth_mail" title="E-mail the corresponding author ; Anna-Fleur D. Vinkb ; Erik H. Niksa ; Ruben H. Westhuisa ; Erik W. van Zwetc ; Robert H. de Meela ; Ricardo Rojas-Garcí ; ad ; Jordi Dí ; az-Manerad ; Jan B. Kukse ; Rinse Kloosterb ; Kirsten Straasheijmb ; Amelia Evolif ; Isabel Illad ; Silvè ; re M. van der Maarelb ; Jan J. Verschuurena
- 关键词：AChR ; Acetylcholine receptor ; DSS ; Disease severity score ; MuSK-Ig1 ; MuSK Ig-like 1 domain ; Fz-like domain ; Frizzled-like domain ; LEMS Lambert-Eaton ; Myasthenic syndrome ; Lrp4 ; Low-density lipoprotein receptor-related protein 4 ; MIR ; Main immunogenic region ; MuSK ; Muscle specific kinase ; MG ; Myasthenia gravis ; PV ; Pemphigus Vulgaris ; RIA ; Radio-immunoprecipitation assay
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：291
- 期：Complete
- 页码：82-88
- 全文大小：826 K
文摘
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Autoantibodies against MuSK-Ig1 are biomarkers of disease severity in MuSK MG.
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The immune response against MuSK in the majority of patients remains confined to the N-terminus.
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Females have a more confined immune response against MuSK than men.
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Pyridostigmine responsiveness and side effects do not correlate with specific epitope patterns.