Mycotoxin detoxifiers attenuate deoxynivalenol-induced pro-inflammatory barrier insult in porcine enterocytes as an in vitro evaluation model of feed mycotoxin reduction

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• 作者：Seong-Hwan Park^a ; ^b ; ^d ; Juil Kim^a ; ^d ; Dongwook Kim^c ; Yuseok Moon^a ; ^b ; ^d ; ^moon@pnu.edu
• 关键词：Mycotoxin detoxifiers ; Porcine enterocytes ; Deoxynivalenol
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：38
• 期：Complete
• 页码：108-116
• 全文大小：965 K
• 卷排序：38

文摘

Efficacies of mycotoxin detoxifiers (MDs) in reducing DON toxicity were evaluated in porcine epithelial monolayer model. MDs attenuated DON-induced disruption of porcine intestinal barrier in vitro. MDs suppressed DON-induced enterocyte chemokine via stress modulators including MAPK and EGR-1.