Potential novel markers to discriminate between active and latent tuberculosis infection in Chinese individuals
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- 作者：Xue-juan Baia ; b ; Yan Lianga ; You-rong Yanga ; Jin-dong Fengc ; Zhan-peng Luod ; Jun-xian Zhanga ; Xue-qiong Wua ; wu-xueqiong@263.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Latent tuberculosis infection ; Mycobacterium tuberculosis ; Tuberculosis ; Rv2029c ; Rv2628 ; Rv1813c ; Diagnosis
- 刊名：Comparative Immunology, Microbiology and Infectious Diseases
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：8-13
- 全文大小：513 K
文摘
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DosR antigens Rv2029c, Rv2628 or Rv1813c induced a higher proportion of T cells producing IFN-γ from LTBI compared to active TB patients in Chinese populations.
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The level of IgG specific for Rv1813c was higher in the TB group than in LTBI and uninfected healthy subjects, but not for Rv2029c and Rv2628.
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BCG vaccination and non-tuberculosis respiratory disease had little influence on the immunological response of Rv2029c and Rv2628.
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T cell response to Rv2628 and antibody response to Rv1813c might be applicable as biomarkers to distinguish TB from LTBI and uninfected individuals.