DosR antigens Rv2029c, Rv2628 or Rv1813c induced a higher proportion of T cells producing IFN-γ from LTBI compared to active TB patients in Chinese populations.
The level of IgG specific for Rv1813c was higher in the TB group than in LTBI and uninfected healthy subjects, but not for Rv2029c and Rv2628.
BCG vaccination and non-tuberculosis respiratory disease had little influence on the immunological response of Rv2029c and Rv2628.
T cell response to Rv2628 and antibody response to Rv1813c might be applicable as biomarkers to distinguish TB from LTBI and uninfected individuals.