Differential cytogenetic profile in advanced chronic myeloid leukemia with sequential lymphoblastic and myeloblastic blast crisis

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• 作者：C. Calder贸n-Cabrera ; I. Montero ; R.M. Morales ; J. S谩nchez ; E. Carrillo ; T. Caballero-Vel谩zquez ; C. Prats ; R. Bernal ; J.M. De Blas ; J.A. P茅rez-Sim贸n
• 关键词：Chronic myeloid leukemia ; Blast crisis ; Cytogenetic abnormalities
• 刊名：Leukemia Research Reports
• 出版年：2013
• 年：2013
• 卷：2
• 期：2
• 页码：79-81
• 全文大小：854 K

文摘

Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase and increases to 40-70% in advanced disease. Progression of CML from chronic phase to accelerated phase or blast crisis is often associated with secondary chromosomal aberrations. We report an exceptional case of CML as debut in lymphoblastic blast crisis and a subsequent progression in myeloblastic blast crisis with rare cytogenetic abnormalities.