Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells
详细信息 查看全文
- 作者：Jun-Hyung Kima ; 1 ; Myeong Seon Jeongb ; 1 ; Dong-Yung Kima ; Song Herb ; Myung-Bok Wiea ; mbwie@kangwon.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zinc oxide nanoparticles ; Apoptosis ; Necrosis ; PI3K/Akt ; Esculetin
- 刊名：Neurochemistry International
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：90
- 期：Complete
- 页码：204-214
- 全文大小：3043 K
文摘
- •
A significant reduction in neuronal viability resulted from application of 15 μg/mL ZnO NPs.
- •
Apoptosis was significantly elevated at 12 h or 24 h after ZnO NP exposure. However, TEM images were showed necrosis.
- •
The concentration of zinc from the dissolution of ZnO NPs increased in proportion to increases in the ZnO NPs concentration.
- •
ZnO NP induced a neuronal injury via elevation of lipoxygenase, PI3 kinase and p-Akt/Akt activities including ROS.