Color Me Infected: Painting Cellular Chromatin with a Viral Histone Mimic
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- 作者：Cason R. King<sup>1sup> ; Tanner M. Tessier<sup>1sup> ; Joe S. Mymryk<sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>3sup><sup> ; sup><sup>jmymryk@uwo.ca" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：adenovirus ; protein VII ; chromatin ; inflammation ; HMGB1 ; viral mimicry
- 刊名：Trends in Microbiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：24
- 期：10
- 页码：774-776
- 全文大小：344 K
文摘
Viruses manipulate cellular chromatin to create a favourable milieu for infection. In several cases, virally-encoded proteins structurally mimic cellular histones to molecularly rewire the host cell. A recent study identified a novel mechanism whereby adenovirus protein VII, a viral histone, binds and manipulates host cell chromatin to suppress inflammatory signalling.