Myoepithelial Tumors: An Update

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• 作者：Vickie Y. Jo ; MD ^{vjo@partners.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Mixed tumor ; Myoepithelioma ; Myoepithelial carcinoma ; Cutaneous ; Soft tissue ; Bone
• 刊名：Surgical Pathology Clinics
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：8
• 期：3
• 页码：445-466
• 全文大小：15855 K

文摘

Primary myoepithelial neoplasms of soft tissue are uncommon, and have been increasingly characterized by clinicopathologic and genetic means. Tumors are classified as mixed tumor/chondroid syringoma, myoepithelioma, and myoepithelial carcinoma, and they share morphologic, immunophenotypic, and genetic features with their salivary gland counterparts. However, soft tissue myoepithelial tumors are classified as malignant based on the presence of cytologic atypia, in contrast to the criterion of invasive growth in salivary gland sites. This review discusses the clinicopathologic and morphologic characteristics, distinct variants, and currently known genetic alterations of myoepithelial neoplasms of soft tissue, skin, and bone.