Chronic expression of Ski induces apoptosis and represses autophagy in cardiac myofibroblasts
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- 作者：Matthew R. Zeglinskia ; 1 ; Jared J.L. Daviesa ; 1 ; Saeid Ghavamib ; Sunil G. Rattana ; Andrew J. Halaykoc ; Ian M.C. Dixona ; idixon@sbrc.ca" class="auth_mail" title="E-mail the corresponding author ;
- 关键词：Myofibroblast ; Ski ; Apoptosis ; Autophagy ; Cardiac fibrosis ; TGFβ1
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1863
- 期：6
- 页码：1261-1268
- 全文大小：1796 K
文摘
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Chronic ectopic Ski expression in primary cardiac myofibroblasts induces apoptosis (85).
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Chronic overexpression of Ski represses autophagy in the same cells (70).
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Caspase-3/7 activity levels are upregulated after 96 h Ski overexpression (80).
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Targeted Ski expression in myofibroblasts is a novel treatment for cardiac fibrosis (86).