Myogenic differentiation depends on the interplay of Grb2 and N-WASP

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• 作者：Payal Mitra ; Thirumaran Thanabalu ; ^{thirumaran@ntu.edu.sg}
• 关键词：N-WASP ; Myogenesis ; F-actin ; SH3 domain
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1864
• 期：3
• 页码：487-497
• 全文大小：2011 K
• 卷排序：1864

文摘

Expression of Grb2 is enhanced under differentiation conditions. Grb2 is a negative regulator of myogenic differentiation of C2C12 cells. C-terminal SH3 domain of Grb2 is critical for inhibition of myogenesis. Grb2 reduced filamentous actin under myogenic differentiation condition. Expression of N-WASP rescued Grb2 mediated inhibition of myogenesis.