Myf5 and Myogenin in the development of thymic myoid cells — Implications for a murine in vivo model of myasthenia gravis
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- 作者：Bo Hua ; 1 ; Katja Simon-Kellera ; 1 ; Stefan Kü ; fferb ; Philipp Strö ; belb ; Thomas Braunc ; Alexander Marxa ; Stefan Porubskya ; stefan.porubsky@umm.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：AChR ; Acetylcholine receptor ; AIRE ; Autoimmune regulator ; EOMG ; Early onset myasthenia gravis ; LOMG ; Late onset myasthenia gravis ; LRP4 ; Low-density lipoprotein receptor-related protein 4 ; MG ; Myasthenia gravis ; MHC ; Major histocompatibility complex ; MuSK ; Muscle-specific tyrosine kinase ; p.c. ; Post-conceptionem ; TAMG ; Thymoma associated myasthenia gravis ; TMC ; Thymic myoid cells ; WT ; Wild type
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：277
- 期：Complete
- 页码：76-85
- 全文大小：3703 K
文摘
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Development of thymic myoid cells (TMC) depends on Myf5 and Myog.
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Myf5- and Myog-deficient mice show a partial or complete, respectively, loss of TMC.
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Myf5- and Myog-deficiency might be used as a model for studying myasthenia gravis.